Two sample MR report

Telomere_length against AmygNuclei rh volume Basal-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0951585	0.0994068	0.3493257
Weighted median	23	0.0159771	0.0509771	0.7539639
Inverse variance weighted	23	-0.0014494	0.0388455	0.9702356
Simple mode	23	0.0157127	0.0898911	0.8628376
Weighted mode	23	0.0210020	0.0606037	0.7322245

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.69352	21	0.8380104
Inverse variance weighted	15.80822	22	0.8252886

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059317	0.0056182	0.3030579

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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