Two sample MR report

Telomere_length against AmygNuclei rh volume Anterior-amygdaloid-area-AAA

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0282872	0.1114000	0.8020231
Weighted median	23	-0.0278105	0.0580530	0.6318997
Inverse variance weighted	23	0.0167921	0.0427265	0.6943091
Simple mode	23	-0.0801210	0.0862346	0.3629173
Weighted mode	23	-0.0447187	0.0640311	0.4922498

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.37308	21	0.1925791
Inverse variance weighted	26.61580	22	0.2261833

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027679	0.006296	0.6647049

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008121	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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