Two sample MR report

Telomere_length against AmygNuclei rh volume Accessory-Basal-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0616818	0.0994061	0.5416024
Weighted median	23	0.0048865	0.0554493	0.9297772
Inverse variance weighted	23	-0.0383903	0.0388453	0.3230116
Simple mode	23	0.0146420	0.0946323	0.8784490
Weighted mode	23	0.0197195	0.0738928	0.7920578

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.02497	21	0.6474234
Inverse variance weighted	19.22107	22	0.6316406

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0061444	0.0056182	0.2864905

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006121	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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