Two sample MR report

Telomere_length against AmygNuclei lh volume Whole-amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0317734	0.0994064	0.7524056
Weighted median	23	-0.0381066	0.0536537	0.4775597
Inverse variance weighted	23	-0.0032018	0.0388455	0.9343101
Simple mode	23	-0.0238052	0.0924299	0.7991489
Weighted mode	23	-0.0353986	0.0611568	0.5685920

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.52161	21	0.8461692
Inverse variance weighted	14.66771	22	0.8760992

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021475	0.0056182	0.7061291

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004447	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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