Two sample MR report

Telomere_length against AmygNuclei lh volume Paralaminar-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1469819	0.1033696	0.1697363
Weighted median	23	0.0595823	0.0570407	0.2962278
Inverse variance weighted	23	0.0199170	0.0411071	0.6280215
Simple mode	23	0.1502514	0.0881938	0.1025329
Weighted mode	23	0.0594654	0.0664937	0.3808404

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.70816	21	0.3597336
Inverse variance weighted	24.63655	22	0.3147688

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078017	0.0058422	0.1960364

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007545	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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