Two sample MR report

Telomere_length against AmygNuclei lh volume Medial-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2295072	0.1036604	0.0380250
Weighted median	23	0.0733912	0.0580992	0.2065154
Inverse variance weighted	23	0.0814489	0.0417838	0.0512604
Simple mode	23	0.1247231	0.0875969	0.1685251
Weighted mode	23	0.0985557	0.0700525	0.1734324

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.83622	21	0.3527724
Inverse variance weighted	25.45447	22	0.2758391

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0090908	0.0058587	0.1356793

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009045	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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