Two sample MR report

Telomere_length against AmygNuclei lh volume Lateral-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0281918	0.0994064	0.7794927
Weighted median	23	0.0004971	0.0557366	0.9928843
Inverse variance weighted	23	0.0205058	0.0388456	0.5975831
Simple mode	23	-0.0359159	0.0883075	0.6881478
Weighted mode	23	-0.0254575	0.0612217	0.6815665

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.57340	21	0.8437332
Inverse variance weighted	14.58046	22	0.8796050

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004719	0.0056182	0.9338529

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004503	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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