Two sample MR report

Telomere_length against AmygNuclei lh volume Corticoamygdaloid-transitio

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0503767	0.0994054	0.6175889
Weighted median	23	-0.0111173	0.0595593	0.8519276
Inverse variance weighted	23	-0.0424675	0.0388452	0.2742849
Simple mode	23	0.0163680	0.1075023	0.8803721
Weighted mode	23	-0.0192669	0.0848674	0.8225020

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.84108	21	0.5313466
Inverse variance weighted	20.87065	22	0.5287443

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057006	0.0056182	0.3218088

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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