Two sample MR report

Telomere_length against AmygNuclei lh volume Cortical-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2054504	0.0994056	0.0513041
Weighted median	23	0.0685016	0.0566346	0.2264564
Inverse variance weighted	23	0.0544814	0.0401855	0.1751792
Simple mode	23	0.1879861	0.1017878	0.0782653
Weighted mode	23	0.0796531	0.0662311	0.2418950

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.82184	21	0.4698696
Inverse variance weighted	23.54404	22	0.3715752

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092695	0.0056182	0.1138405

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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