Two sample MR report

Telomere_length against AmygNuclei lh volume Central-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0599305	0.1042933	0.5716439
Weighted median	23	-0.0404793	0.0543845	0.4566849
Inverse variance weighted	23	0.0017075	0.0402070	0.9661262
Simple mode	23	-0.0461775	0.0854860	0.5945023
Weighted mode	23	-0.0391162	0.0637577	0.5458290

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.11561	21	0.3378454
Inverse variance weighted	23.56938	22	0.3701993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037846	0.0058944	0.5277826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007143	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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