Two sample MR report

Telomere_length against AmygNuclei lh volume Basal-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0096122	0.0994065	0.9238845
Weighted median	23	-0.0487805	0.0537254	0.3638999
Inverse variance weighted	23	-0.0209309	0.0388454	0.5900072
Simple mode	23	-0.0781755	0.0923920	0.4065907
Weighted mode	23	-0.0588134	0.0632101	0.3622396

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.85826	21	0.7196617
Inverse variance weighted	16.87356	22	0.7703012

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000695	0.0056182	0.9027308

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005201	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

Leave-one-out sensitivity analysis

plot of chunk chunk8