Two sample MR report

Telomere_length against AmygNuclei lh volume Anterior-amygdaloid-area-AAA

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0579670 0.1093411 0.6015704
Weighted median 23 0.0310373 0.0535136 0.5619225
Inverse variance weighted 23 0.0032304 0.0420383 0.9387473
Simple mode 23 -0.0118997 0.0909422 0.8970837
Weighted mode 23 0.0225154 0.0690540 0.7474636

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 25.40745 21 0.2299486
Inverse variance weighted 25.76529 22 0.2618954

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0033608 0.0061797 0.5922743

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007809 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8