Two sample MR report

Telomere_length against AmygNuclei lh volume Accessory-Basal-nucleus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0100154	0.0994053	0.9207024
Weighted median	23	-0.0850687	0.0559897	0.1286707
Inverse variance weighted	23	-0.0302475	0.0388452	0.4361754
Simple mode	23	-0.0752174	0.1033153	0.4742687
Weighted mode	23	-0.1033257	0.0740757	0.1769809

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.73582	21	0.5380452
Inverse variance weighted	19.78472	22	0.5965042

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012423	0.0056182	0.8271399

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006179	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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